How CRESTOR May Help

Get your numbers down with CRESTOR

Physicians have prescribed CRESTOR® (rosuvastatin) over 15 million times – ask if it’s right for you.[1]
When diet and exercise alone are not enough, CRESTOR is prescribed along with diet in adults to lower high cholesterol and to slow plaque buildup in arteries as part of a treatment plan to lower cholesterol to goal.

Crestor lowers bad cholesterol up to 55%*

*At 20-mg dose vs 7% with placebo.

See how CRESTOR compared to 2 other statins

  • In the ECLIPSE clinical trial

    CRESTOR lowered bad (LDL) cholesterol in high-risk patients[†a] more than Lipitor® (atorvastatin calcium)

     

    About the ECLIPSE Trial: ECLIPSE was a 24-week clinical trial involving 1,036 high-risk patients who had high cholesterol at the beginning of the trial. Patients were given one of the following statin medications: CRESTOR or Lipitor. The researchers then compared the percentage of patients achieving bad (LDL) cholesterol goal at different dosages and time points (6, 12, 18, 24 weeks) between the two medicines.

  • In the MERCURY II clinical trial

    high-risk patients[†b] who switched to CRESTOR had greater reductions in bad (LDL) cholesterol than those staying on Lipitor® (atorvastatin calcium) or Zocor® (simvastatin)[‡]

     

    About the MERCURY II Trial: MERCURY II was a 16-week clinical trial of patients with high cholesterol and an additional risk factor. For the first 8 weeks, patients were given one of the following: CRESTOR 20 mg, Lipitor 10 mg, Lipitor 20 mg, Zocor 20 mg, or Zocor 40 mg once daily. For the next 8 weeks, patients either remained on these treatments or were switched as follows: Half from Lipitor 10 mg or Zocor 20 mg to CRESTOR 10 mg once daily; half from Lipitor 20 mg or Zocor 40 mg to CRESTOR 20 mg once daily.

† †a †b Definition of high-risk patients: Patients aged 18 or older with high cholesterol and a history of narrowing or blockage of the coronary arteries (coronary heart disease) or evidence of plaque buildup in their arteries that can narrow the arteries over time, diabetes, or a high risk of developing coronary heart disease over the next 10 years.

‡^Lipitor 10 mg → CRESTOR 10 mg vs Lipitor 10 mg; Lipitor 20 mg → CRESTOR 20 mg vs Lipitor 20 mg. Zocor 20 mg → CRESTOR 10 mg vs Zocor 20 mg; Zocor 40 mg → CRESTOR 20 mg vs Zocor 40 mg.

Lipitor is a registered trademark of Upjohn Manufacturing Ireland Unlimited Company, a Viatris Company.

Zocor is a registered trademark of Organon & Co.

Next: Discover how CRESTOR works to help lower cholesterol

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IS CRESTOR RIGHT FOR YOU?

Talk to your doctor to find out if CRESTOR is right for you.

Is Crestor Right for You?

IMPORTANT SAFETY INFORMATION ABOUT CRESTOR TABLETS

  • CRESTOR is not right for everyone.
  • Do not take CRESTOR if you have liver problems or are allergic to rosuvastatin or any of the ingredients in CRESTOR.
  • Call your healthcare provider right away if you have unexplained muscle pain or weakness, especially with fever; have muscle problems that do not go away even after your healthcare provider told you to stop taking CRESTOR; feel unusually tired; or have loss of appetite, upper belly pain, dark urine, or yellowing of skin or eyes. These could be signs of rare but serious side effects.
  • Your healthcare provider may do blood tests to check your liver before starting treatment and if you have symptoms of liver problems while taking CRESTOR.
  • CRESTOR may cause you to have protein and blood in your urine.
  • Elevated blood sugar levels have been reported with statins, including CRESTOR.
  • The most common side effects may include headache, nausea, muscle aches, weakness, and constipation.
  • Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. CRESTOR may affect the way other medicines work, and other medicines may affect how CRESTOR works.
  • Tell your healthcare provider if you are pregnant or may become pregnant. CRESTOR can pass in breast milk and may harm your baby. Do not breastfeed while taking CRESTOR.
  • Talk to your healthcare provider for more information about CRESTOR.

Approved Uses

  • Prescription CRESTOR is used:
    • to reduce the risk of major adverse cardiovascular (CV) events, such as death from cardiovascular disease, heart attack, stroke or the need for procedures to improve blood flow to the heart called arterial revascularization in adults who do not have known heart disease but do have certain additional risk factors
  • CRESTOR is used along with diet to:
    • lower the level of low-density lipoprotein cholesterol (LDL-C) or “bad” cholesterol in adults with primary hyperlipidemia
    • slow the buildup of fatty deposits (plaque) in the walls of blood vessels
    • treat adults and children 8 years of age and older with high blood cholesterol due to heterozygous familial hypercholesterolemia (HeFH), an inherited condition that causes high levels of LDL-C
    • along with other cholesterol lowering treatments or alone if such treatments are unavailable in adults and children 7 years of age and older with homozygous familial hypercholesterolemia (HoFH), an inherited condition that causes high levels of LDL-C
    • to treat adults with primary dysbetalipoproteinemia (an inherited condition that causes high levels of cholesterol and fat) or hypertriglyceridemia

Please read the Patient Information and full Prescribing Information.

You may report side effects related to AstraZeneca products.

References:

  • 1a 1b 1c 1d CRESTOR® (rosuvastatin) [prescribing information]. Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2024.
  • ^ Lipitor® (atorvastatin calcium) [prescribing information]. Morgantown, WV: Viatris Specialty LLC, 2024.
  • ^ Zocor® (simvastatin) [Prescribing Information]. Jersey City, NJ: Organon & Co.; 2023.
  • ^ Davidson M, Ma P, Stein EA, et al. Comparison of effects on low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with rosuvastatin versus atorvastatin in patients with type IIa or IIb hypercholesterolemia. Am J Cardiol. 2002;89:268–275.
  • ^ Schwartz GG, Bolognese MA, Tremblay BP, et al. Efficacy and safety of rosuvastatin and atorvastatin in patients with hypercholesterolemia and a high risk of coronary heart disease: A randomized, controlled trial. Am Heart J. 2004;148:e4.
  • ^ Olsson A, Istad H, Luurila O, et al. Effects of rosuvastatin and atorvastatin compared over 52 weeks of treatment in patients with hypercholesterolemia. Am Heart J. 2002;144:1044-1051.

Reference:

^ Data on File, US-62651. AstraZeneca Pharmaceuticals LP.

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IMPORTANT SAFETY INFORMATION AND APPROVED USES FOR CRESTOR TABLETS

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