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Risk Factors for Plaque Buildup

What risk factors contribute to plaque buildup in arteries?

Why is your doctor so concerned with lowering high cholesterol? One reason is that if left untreated, high levels of bad (LDL) cholesterol may lead to plaque buildup that can narrow or begin to clog arteries over time—a progressive disease called atherosclerosis. If you have high cholesterol plus any of the other risk factors listed below, you could be at increased risk for plaque buildup in your arteries compared to someone who has high cholesterol alone.

That’s why it is so important to get your cholesterol to goal.

High cholesterol + any of these risk factors may put you at increased risk for plaque buildup:

Risk Factors for Plaque Buildup

It's important to discuss all your risk factors for atherosclerosis when considering your cholesterol-management plan with your doctor.

CRESTOR® (rosuvastatin calcium) is FDA approved to slow the progression of plaque buildup. Be sure to talk to your doctor about all of your risk factors that can contribute to plaque buildup and ask if CRESTOR is right for you.

See what an expert says

Dr. Pamela Kushner on Plaque Buildup Risk Factors

Dr Pamela Kushner explains why some people are at even greater risk for plaque buildup. Learn about plaque buildup in arteries and risk factors that may contribute to it to help you have a more productive conversation with your doctor about lowering your cholesterol to goal.

Watch video

Important questions to ask your doctor

  • Does my health history indicate that I have a higher risk of atherosclerosis?
  • How can CRESTOR help slow the buildup of plaque and get my cholesterol to a healthy level?
  • What are some of the common lifestyle changes that can help me manage my risk factors?



Important Safety Information About CRESTOR Tablets


  • CRESTOR is not right for everyone. Do not take CRESTOR if you are nursing, pregnant or may become pregnant; have liver problems; or have had an allergic reaction to CRESTOR
  • Your doctor should do blood tests to check your liver before starting treatment and if you have symptoms of liver problems while taking CRESTOR
  • Call your doctor right away if you:
    • Have unexplained muscle pain or weakness, especially with fever
    • Have muscle problems that do not go away even after your doctor told you to stop taking CRESTOR
    • Feel unusually tired
    • Have loss of appetite, upper belly pain, dark urine, or yellowing of skin or eyes
  • These could be signs of rare but serious side effects
  • Elevated blood sugar levels have been reported with statins, including CRESTOR
  • Side effects: The most common side effects may include headache, muscle aches, abdominal pain, weakness, and nausea. Memory loss and confusion have also been reported with statins, including CRESTOR
  • Tell your doctor and pharmacist about other medicines you are taking

Talk to your doctor about prescription CRESTOR.

Approved Uses for CRESTOR

When diet and exercise alone aren't enough to lower cholesterol, adding CRESTOR can help.

In adults, CRESTOR is prescribed along with diet to lower high cholesterol and to slow plaque buildup in arteries as part of a treatment plan to lower cholesterol to goal.

Prescribing Information with Patient Information  (PDF - 152k) 


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

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The information on this Web site should not take the place of talking with your doctor or health care professional. If you have any questions about your condition, or if you would like more information about CRESTOR, talk to your doctor or pharmacist. Only you and your health care professional can decide if CRESTOR is right for you.