print_label | resize_label

Glossary of Terms

Ankle/brachial index

The ankle/brachial index is one way your doctor can diagnose plaque buildup in arteries or other vascular diseases. The test is done by measuring your blood pressure at the ankle and in the arm and dividing the systolic pressure in the ankle by the systolic pressure in the arm.

Artery or arteries

Arteries are relatively thick-walled blood vessels that carry oxygenated blood away from the heart to the rest of the body. They play a major role in the function of the cardiovascular system. Watch "Section of an Artery Showing the Lumen" Video

Atherosclerosis

Atherosclerosis is a disease of the arteries caused by progressive plaque buildup in the arteries. Bad (LDL) cholesterol along with other health factors, such as diabetes, high blood pressure, family history of early heart disease, age, obesity, and smoking can all play a role in the formation of plaque. This plaque can start building up in arteries in early adulthood and gets worse over time. This plaque buildup over time can lead to narrowing of the arteries. Watch "Plaque Buildup" Video

Body mass index (BMI)

BMI is an estimation of body fat based on height and weight. According to guidelines from the National Institutes of Health, a normal BMI range is 18.5 to 24.9. A BMI of 25 to 29.9 is considered overweight, and a BMI of 30 or more is considered obese.

Bruits

Pronounced “brew-ees,” bruits are the faint whooshing noises caused by the turbulence of blood rushing through restricted arteries. This is a common way for your doctor to look for signs of plaque buildup. Watch "Plaque Buildup" Video

Calorie

A calorie is a measure of energy that you get from the food you eat. A calorie from food is sometimes called a kilocalorie. There aren't different types of calories—the energy you get from one calorie in a piece of lettuce is the same as the energy you get from one calorie in a piece of meat.

Cholesterol

Cholesterol is a fatty substance, also called a lipid, that's produced by the liver and found in your bloodstream. It's also found in foods high in saturated fat, like fatty meats, egg yolks, shellfish, and whole-milk dairy products. Cholesterol is also a vital part of the structure and functioning of our cells.

Clinical trial

Clinical trials are research studies conducted to evaluate the safety and effectiveness of medications. In a typical clinical trial, groups of patients are asked to take a certain medication. This may be a specific dose of an existing medication, a dose of a new medication, or a placebo (sugar pill). Researchers then gather data over time and analyze the results.

Diabetes

Diabetes is a disease in which either the body does not produce enough insulin or the body's cells do not effectively use the insulin produced. This causes above-normal blood sugar levels. Diabetes is a serious condition that can cause complications ranging from numbness to loss of vision to coma. It is also a major cause of heart disease and stroke. About 25.8 million Americans have diabetes.

Dietary (soluble) fiber

A type of fiber that is important to your health. It slows digestion and extends the feeling of fullness, and can also lower your bad (LDL) cholesterol. This fiber can be found in certain foods, such as peas, beans, and apples.

ECLIPSE trial

ECLIPSE was a 24-week clinical trial involving 1,036 high-risk patients who had high cholesterol at the beginning of the trial. Patients were given one of the following statin medications: CRESTOR® (rosuvastatin calcium) or Lipitor® (atorvastatin calcium). The researchers then compared the percentage of patients achieving bad (LDL) cholesterol goal at different dosages and time points (6, 12, 18, 24 weeks) between the two medicines. At each time point and dose comparison, significantly more high-risk patients taking CRESTOR achieved the guideline recommended goal of <100 mg/dL for bad (LDL) cholesterol versus Lipitor. The most common adverse events were muscle aches and pains, chest pains, and inflammation of the nose and throat.

Fasting lipid profile

Also known as a cholesterol test, this is used to determine your levels of LDL cholesterol, HDL cholesterol, and triglycerides. You will be asked to fast before you have a test to measure your blood cholesterol level. This means you have nothing to eat or drink—except for water—for 9 to 12 hours before the test. Watch "LDL-C" Video

Fat

A class of energy-rich food that comes from a substance found mainly in animal tissue and certain plants. There are
9 calories in each gram of fat—more than twice the calories in protein or carbohydrates.

Gram

A measure of weight in the metric system. Approximately 28 grams make 1 ounce.

High blood pressure

When the pressure at which blood is pumped through the arteries by the heart is above an average range, it is called high blood pressure, or hypertension. Blood pressure is recorded as two numbers—the systolic pressure (as the heart beats) over the diastolic pressure (as the heart relaxes).

High blood sugar

An excessive amount of sugar in the blood, also known as hyperglycemia, is a sign of diabetes.

HDL-C

“HDL-C” stands for high-density lipoprotein cholesterol. HDL cholesterol is a lipoprotein that helps return cholesterol to the liver, where it can be eliminated from the body. As a rule, you want your HDL cholesterol high. Watch "HDL-C" Video

LDL-C

“LDL-C” stands for low-density lipoprotein cholesterol. LDL is a lipoprotein that carries cholesterol throughout the bloodstream as LDL cholesterol, or LDL-C. If you have too much LDL-C circulating in your bloodstream, it can lead to plaque buildup in your arteries. That's why it's so important to talk to your doctor. As a rule, you want to keep your LDL-C low. Watch "LDL-C" Video

Monounsaturated fat

An unsaturated fat found primarily in plant-based foods such as olive and canola oils. Monounsaturated fats are liquid at room temperature. Eating more monounsaturated fats (instead of saturated fats such as butter and lard) can help lower cholesterol.

National Cholesterol Education Program (NCEP)

Launched in 1985 by the National Heart, Lung, and Blood Institute, a part of the National Institutes of Health, the NCEP works to reduce the incidence of high cholesterol and related health conditions in the US by establishing guidelines and recommendations on cholesterol management and promoting them to health care professionals, patients, and the general public.

National Institutes of Health (NIH)

The federal government's centralized source for health information and research.

Obese or obesity

Excessive fat in body tissues. Obesity increases the danger of developing many health conditions, including diabetes and certain heart problems. The National Heart, Lung, and Blood Institute defines being obese as having a BMI of 30 or greater.

Omega-3 fatty acids

A substance found in fish oil and some plants that may be helpful in reducing high triglycerides.

Overweight

Weighing more than what is healthy for your age and size. The National Heart, Lung, and Blood Institute defines overweight as having a body mass index (BMI) of 25 to 29.9.

Plaque

Plaque is the fatty deposits and other cells that can build up in the walls of your arteries. One major cause is high levels of bad (LDL) cholesterol. Other health factors, such as a family history of early heart disease, diabetes, high blood pressure, cigarette smoking, and being obese, can also play a role. Watch "Plaque Buildup" Video

Polyunsaturated fat

An unsaturated fat found primarily in plant-based foods such as corn, sunflower, safflower, and soybean oils. Polyunsaturated fats are liquid or soft at room temperature. Eating more polyunsaturated fats (instead of saturated fats such as butter and lard) can lower cholesterol.

Protein

Protein is composed of a chain of amino acids. Our muscles, organs, and glands are largely made of protein. Our bodies can produce 13 of the 20 or so amino acids we need to make proteins, but the other amino acids (about 9) can only be found in food. There are 4 calories in each gram of protein.

Saturated fat

Saturated fats are usually found in animal products, including fatty meat and dairy products, and are usually solid at room temperature. However, they are also found in some vegetable oils, including coconut and palm oils.

Side effects

Secondary effects of a drug or therapy (as opposed to the main therapeutic effect) that are undesirable. The most common side effects of CRESTOR are headache, muscle aches, abdominal pain, weakness, and nausea.

Stanols and sterols

Stanols and sterols are chemicals present in certain plants that have been shown to help reduce high cholesterol. They may be found as ingredients in certain margarines and salad dressings that claim to lower cholesterol.

Statin

Statins are a type of drug used to reduce levels of bad (LDL) cholesterol in the blood. Statins block a substance (an enzyme) in the liver, causing the liver to make less cholesterol. Statins may also help the liver absorb and break down cholesterol already in the blood.

STELLAR trial

STELLAR was a 6-week clinical trial involving 2,240 patients who had high cholesterol at the beginning of the trial. Patients were given different dosages of one of the following statin medications: CRESTOR® (rosuvastatin calcium), Lipitor® (atorvastatin calcium), Zocor® (simvastatin), and Pravachol® (pravastatin sodium). The researchers then compared the changes in the patients' LDL-C between the different drugs and dosages. In the STELLAR trial, the occurrence of adverse events was similar between treatment groups. The most common adverse events were pain, sore throat, muscle ache, and headache.

Triglycerides

Triglycerides are another fat produced by the liver and also found in food. Like high cholesterol, they can be dangerous to your health. As a rule, you want to keep your triglycerides low.

Unsaturated fat

Unsaturated fat is found primarily in plant-based foods and is usually liquid at room temperature. Eating more unsaturated fat (instead of saturated fat such as butter and lard) can help lower cholesterol. There are two main types of unsaturated fat: monounsaturated (such as olive and canola oils) and polyunsaturated (such as corn, sunflower, safflower, and soybean oils).

Important Safety Information about CRESTOR® (rosuvastatin calcium) Tablets

  • CRESTOR is not right for everyone. Do not take CRESTOR if you are nursing, pregnant or may become pregnant; have liver problems; or have had an allergic reaction to CRESTOR
  • Your doctor should do blood tests to check your liver before starting treatment with CRESTOR and if you have symptoms of liver problems while taking CRESTOR
  • Call your doctor right away if you:
    • Have unexplained muscle pain or weakness, especially with fever
    • Have muscle problems that do not go away even after your doctor told you to stop taking CRESTOR
    • Feel unusually tired
    • Have loss of appetite, upper belly pain, dark urine, or yellowing of skin or eyes
  • These could be signs of rare but serious side effects
  • Elevated blood sugar levels have been reported with statins, including CRESTOR
  • Side effects: The most common side effects may include headache, muscle aches, abdominal pain, weakness, and nausea. Memory loss and confusion have also been reported with statins, including CRESTOR
  • Tell your doctor and pharmacist about other medicines you are taking

Talk to your doctor about prescription CRESTOR.

Approved Uses for CRESTOR

When diet and exercise alone aren't enough to lower cholesterol, adding CRESTOR can help.

In adults, CRESTOR is prescribed along with diet to lower high cholesterol and to slow the buildup of plaque in arteries as part of a treatment plan to lower cholesterol to goal.

Prescribing Information with Patient Information  (PDF - 152k) 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

FlagThis site is intended for US consumers only.

The information on this Web site should not take the place of talking with your doctor or health care professional. If you have any questions about your condition, or if you would like more information about CRESTOR, talk to your doctor or pharmacist. Only you and your health care professional can decide if CRESTOR is right for you.