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Helping you encourage at-risk patients with high cholesterol to treat their condition continues to be a priority for AstraZeneca. To assist you in helping your patients achieve their treatment goals, we’ve created a program for patients who are taking CRESTOR^® (rosuvastatin calcium), as well as a Take Action Kit to help raise awareness of atherosclerosis.

CRESTOR 360°™ Patient Support Program

The CRESTOR 360° Program was designed to encourage at-risk patients to overcome logistical and/or behavioral barriers to adherence. The program offers information — online and through the mail — that can be customized to fit each patient’s interests.

At-risk patients who enroll in the free program will receive

• Information about cholesterol and atherosclerosis
• Patient-selected content about topics such as diet, fitness, and managing stress as part of living a healthy lifestyle
• Optional weekly tip e-mails
• Links to Web sites and online tools
• A Savings Card that allows qualified patients to pay no more than $25 for their next 12 prescriptions for CRESTOR (Subject to eligibility. Restrictions apply)

To get your at-risk patients enrolled in the CRESTOR 360° Program, simply ask your CRESTOR representative for CRESTOR 360° Program Starter Kits or visit AZOnDemand™. You can also enroll individual patients in the CRESTOR 360° Program by visiting our consumer site.

Take Action Kit

As part of AstraZeneca’s initiative to raise understanding of atherosclerosis, we’ve created the Take Action Kit. The program aims to prepare at-risk patients to have a productive discussion about atherosclerosis during their next office visit. The Kit includes

• A series of informative brochures about atherosclerosis and risk factors patients may need to be concerned about
• Information about CRESTOR
• Questions to discuss during their office visit
• A 30-day free trial offer for CRESTOR

Let your patients know they can sign up to receive a Take Action Kit by visiting our consumer site.

At times, financial help is what patients need most. For those times, please consider these money-saving offers.

• CRESTOR is indicated^# as an adjunct to diet to reduce elevated total-C, LDL-C, ApoB, non-HDL-C, and triglycerides, and to increase HDL-C in adult patients with primary hyperlipidemia or mixed dyslipidemia and to slow the progression of atherosclerosis in adult patients as part of a treatment strategy to lower total-C and LDL-C to target levels

Important Safety Information for CRESTOR tablets

• CRESTOR is contraindicated^# in patients with a known hypersensitivity to any component of this product, in patients with active liver disease, which may include unexplained persistent elevations of hepatic transaminase levels, in women who are pregnant or may become pregnant, and in nursing mothers
• Cases of myopathy and rhabdomyolysis with acute renal failure secondary to myoglobinuria have been reported with HMG-CoA reductase inhibitors, including CRESTOR. These risks can occur at any dose level but are increased at the highest dose (40 mg)
• CRESTOR should be prescribed with caution in patients with predisposing factors for myopathy (eg, age ≥65 years, inadequately treated hypothyroidism, renal impairment). The risk of myopathy during treatment with CRESTOR may be increased with concurrent administration of some other lipid-lowering therapies (fibrates or niacin), gemfibrozil, cyclosporine, lopinavir/ritonavir, or atazanavir/ritonavir
• Therapy with CRESTOR should be discontinued if markedly elevated CK levels occur or myopathy is diagnosed or suspected. All patients should be advised to promptly report unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever
• It is recommended that liver enzyme tests be performed before and at 12 weeks following both the initiation of therapy and any elevation of dose, and periodically (eg, semiannually) thereafter. Should an increase in ALT or AST of >3 times ULN persist, reduction of dose or withdrawal of CRESTOR is recommended
• CRESTOR should be used with caution in patients who consume substantial quantities of alcohol and/or have a history of chronic liver disease
• CRESTOR significantly increased INR in patients receiving coumarin anticoagulants. In patients taking coumarin anticoagulants and CRESTOR concomitantly, INR should be determined before starting CRESTOR and frequently enough during early therapy to ensure that no significant alteration of INR occurs
• Dipstick-positive proteinuria and microscopic hematuria were observed among patients treated with CRESTOR. These findings were more frequent in patients taking CRESTOR 40 mg, though it was generally transient and was not associated with worsening renal function. Although the clinical significance of this finding is unknown, dose reduction should be considered for patients on CRESTOR therapy with unexplained persistent proteinuria and/or hematuria during routine urinalysis testing
• Increases in HbA1c and fasting serum glucose levels have been reported with HMG-CoA reductase inhibitors, including CRESTOR
• In the controlled clinical trials database, the most common adverse reactions were headache (3.7%), myalgia (3.1%), abdominal pain (2.6%), asthenia (2.5%), and nausea (2.2%)^‡‡
• The dose range for CRESTOR is 5 mg to 40 mg orally once daily. The usual starting dose is 10 mg to 20 mg. Patients initiating CRESTOR therapy or switching from another statin should begin treatment with CRESTOR at the appropriate starting dose. After initiation or upon titration of CRESTOR, lipid levels should be analyzed within 2 to 4 weeks and the dosage adjusted accordingly. CRESTOR 40 mg should be used only for those patients not achieving their LDL-C goal with 20 mg