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Crestor® (rosuvastatin calcium)



 

Clinical Trial Results

Often doctors use (glossary term)clinical trial results to help them evaluate different medications.

The interactive tool below shows how (video)LDL (bad) cholesterol was lowered in a clinical trial known as (glossary term)STELLAR (comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses).

This tool is not meant to show which cholesterol medication is right for you. Ask your doctor about clinical trial results involving CRESTOR® (rosuvastatin calcium) and what the results mean. Only your doctor can decide if CRESTOR is right for you.

Important Safety Information about CRESTOR® (rosuvastatin calcium) Tablets

  • CRESTOR is not right for everyone. Do not take CRESTOR if you are nursing, pregnant or may become pregnant; have liver problems; or have had an allergic reaction to CRESTOR
  • Your doctor should do blood tests to check your liver before starting treatment with CRESTOR and if you have symptoms of liver problems while taking CRESTOR
  • Call your doctor right away if you:
    • Have unexplained muscle pain or weakness, especially with fever
    • Have muscle problems that do not go away even after your doctor told you to stop taking CRESTOR
    • Feel unusually tired
    • Have loss of appetite, upper belly pain, dark urine, or yellowing of skin or eyes
  • These could be signs of rare but serious side effects
  • Elevated blood sugar levels have been reported with statins, including CRESTOR
  • Side effects: The most common side effects may include headache, muscle aches, abdominal pain, weakness, and nausea. Memory loss and confusion have also been reported with statins, including CRESTOR
  • Tell your doctor and pharmacist about other medicines you are taking

About the STELLAR Trial
STELLAR was a 6-week clinical trial involving 2,240 patients who had high cholesterol at the beginning of the trial. Patients were given different dosages of one of the following statin medications: CRESTOR® (rosuvastatin calcium), Lipitor® (atorvastatin calcium), Zocor® (simvastatin), and Pravachol® (pravastatin sodium). The researchers then compared the changes in the patients' LDL-C between the different drugs and dosages. In the STELLAR trial, the occurrence of adverse events was similar between treatment groups. The most common adverse events were pain, sore throat, muscle ache, and headache.

More Facts to Consider About CRESTOR

When diet and exercise alone aren't enough to lower your cholesterol, it's important to discuss your treatment options with your doctor and choose a medication that's right for you.



Please see full Prescribing Information for CRESTOR
http://www.astrazeneca-us.com/cgi-bin/az_pi.cgi?product=crestor&country=us&popup=no

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

CRESTOR is licensed from SHIONOGI & CO, LTD, Osaka, Japan.



Clinical trial
Clinical trials are research studies conducted to evaluate the safety and effectiveness of medications. In a typical clinical trial, groups of patients are asked to take a certain medication. This may be a specific dose of an existing medication, a dose of a new medication, or a placebo (sugar pill). Researchers then gather data over time and analyze the results.
STELLAR trial
STELLAR was a 6-week clinical trial involving 2,240 patients who had high cholesterol at the beginning of the trial. Patients were given different dosages of one of the following statin medications: CRESTOR® (rosuvastatin calcium), Lipitor® (atorvastatin calcium), Zocor® (simvastatin), and Pravachol® (pravastatin sodium). The researchers then compared the changes in the patients' LDL-C between the different drugs and dosages. In the STELLAR trial, the occurrence of adverse events was similar between treatment groups. The most common adverse events were pain, sore throat, muscle ache, and headache.